Increased plasma conc w/ quinidine, diltiazem; enzyme inhibitors eg, verapamil, cimetidine, erythromycin, itraconazole, ketoconazole, HIV PIs, NNRTIs, quinupristin, dalfopristin, ethanol, nefazodone, grapefruit juice. Increased tacrolimus exposure. Decreased plasma conc w/ enzyme inducers eg, phenytoin, carbamazepine, phenobarb, rifampicin, barbiturates, efavirenz, nevirapine, St. John's wort. Increased risk of severe hypotension, exacerbation of angina, CHF & arrhythmia w/ β-adrenergic blockers eg, propranolol, timolol. Severe hypotension during surgery w/ fentanyl. Increased serum digoxin conc. Increased incidence of severe hypotension w/ methyldopa, hydralazine, captopril, doxazosin.
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